Inbreeding and osteoporosis in Croatian island isolates

Rudan, Igor and Škarić-Jurić, Tatjana and Smolej Narančić, Nina and Janićijević, Branka and Rudan, Diana and Martinović Klarić, Irena and Barać, Lovorka and Peričić, Marijana and Galić, Radoslav and Lethbridge-Čejku, Margaret and Rudan, Pavao (2004) Inbreeding and osteoporosis in Croatian island isolates. Collegium Antropologicum, 28 (2). pp. 585-601. ISSN 0350-6134

CA 2004_2 Rudan et al..pdf

Download (368Kb) | Preview
Official URL:


The aim of this study was to investigate a recessive genetic component in susceptibility to osteoporosis (OP) by comparing its prevalence in isolated villages of three Croatian islands: Brač, Hvar and Korčula with different levels of inbreeding. A random sample of 20-30% adults from 14 villages was obtained, including a total of 1, 389 examinees. The average inbreeding coefficient (F) of examinees from each village population was estimated using Wright's path method (based on genealogical information), isonymy data and average deviation from Hardy-Weinberg expectations for classic set of serogenetic polymorphisms. The variation in environmental, cultural and socio-economic factors between villages was investigated and shown to be minimal. The morphometry of the metacarpal bones was performed on hand-wrist radiographs of both hands in all examinees. OP was defined as values of cortical index smaller than 2 standard deviations based on distribution of values in examinees of the same sex under 45 years of age. Mean values of cortical index (CI) and prevalence of OP (both standardized by age and weighted for the sample size) in each village were correlated to the mean inbreeding coefficient (F). The coefficient of correlation (r) between F values and CI was -0.28 in males (p=0.08) and -0.42 in females (p=0.005), and between F and OP prevalence 0.32 in males (p<0.001) and 0.43 in females (p<0.001). These results indicate a trend of increased susceptibility to osteoporosis with increasing level of inbreeding in isolated communities of Croatian islands.

Item Type: Article
Additional Information: Language: English.
Uncontrolled Keywords: Inbreeding, cortical index, osteoporosis, isolate populations, Croatia
Subjects: G Geography. Anthropology. Recreation > GN Anthropology
R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Depositing User: Karolina
Date Deposited: 19 Jan 2017 10:08
Last Modified: 19 Jan 2017 10:08

Actions (login required)

View Item View Item